Líneas de investigación     Síntesis curricular      Publicaciones

Líneas de investigación

• Diseño y síntesis de moléculas bioactivas quirales para uso agroforestal ó médico.
• Síntesis enantioselectiva y busqueda de catalizadores quirales tipo Ácido Bis Hidroxámico.
• Diseño y síntesis de insecticidas enantiopuros tipo neonicotinoidesima de ultíma generación.

Síntesis Curricular

El Dr. Olivares egreso de la Universidad Nacional Autónoma de México en la carrera Químico Farmacéutico Biólogo. Estudio el doctorado directo en el programa de Ciencias Químicas en el Centro de Investigación y de Estudios Avanzados del IPN (CINVESTAV Zacatenco), bajo la asesoria del Dr. Eusebio Juaristi. Posteriormente, realizo una estancia postdoctoral en el Instituto de Química de la UNAM durante 2009-2011. Continuo con sus estudios postdoctorales en la Universidad de Chicago bajo la asesoria del Profesor Hisashi Yamamoto (2011-2014). Estudio reacciones de epoxidación enantioselectivas catalizadas por BHA´s. Desde abril del 2014 forma parte de la plantilla de investigadores titulares en el Clúster Científico y Tecnológico BioMimic del Instituto de Ecología, A.C. Ha graduado estudiantes de licenciatura, maestría y doctorado. Ha publicado más de 37 artículos de trabajo original, artículos de divulgación/difusión de la ciencia y capítulos de libros. Actualmente forma parte del Sistema Nacional de Investigadores nivel II.

Cursos impartidos

Publicaciones selectas

• López-Rosas, C. A.; Caram-Salas, N.; Olivares-Romero, J. L. Paired Experimental ¹H/¹³C NMR Fingerprint Prediction under Molecule- and Scaffold-Disjoint Evaluation. Chemistry 2026, 8 (10), 140. DOI: 10.3390/chemistry8100140
• Medina-Ortíz, A.; Olivares-Romero, J. L.; Reyes-Luna, A.; Cruz Cruz, D.; et al. Synthesis of Spiro-Bridged 3,4-Dihydrocoumarins through an Organocatalytic Cascade Sequence Diels–Alder/Nucleophilic Ring Closing. Molecules 2026, 31 (16), 2827. DOI: 10.3390/molecules31162827.
• López-Rosas, C. A.; Delgado-Alvarado, E.; Barrera-Méndez, F.; Bonilla-Landa, I.; Olivares-Romero, J. L. Advances in Enantioselective Synthesis and Chiral Resolution of Insecticides. Molecules 2026, 31 (10), 1667. DOI: 10.3390/molecules31101667.
• Rao Marata, S.; Pawar, T. J.; Olivares-Romero, J. L.; Patel, H.; Ahmad, I.; Delgado-Alvarado, E.; Muteeb, G.; Govindappa, N.; Devi, M.; Kokate, S. V.; Basavegowda, L. Design, Synthesis, Molecular Docking, and Antimicrobial Evaluation of Hybrid Peptides Incorporating Unnatural Amino Acids with Enhanced Hydrophobic Side Chains. RSC Adv. 2026, 16 (12), 11090–11099. DOI: 10.1039/D5RA05259A.
• Valtierra-Galván, M.; Rodríguez-Hernández, A.; Bonilla-Landa, I.; et al. A Comparative Study of C2-Symmetric and C1-Symmetric Hydroxamic Acids in Vanadium-Catalyzed Asymmetric Epoxidation of Allylic Alcohols. Molecules 2025, 30 (21), 4311. DOI: 10.3390/molecules30214311.
• Quintero-Beltrán, J. S.; Sánchez-Viveros, G.; Chiquito-Contreras, R. G.; et al. Triazoles Nanoencapsulation in Polylactic Acid to Reduce Phytotoxicity in Roots. Mex. Chem. Soc. 2025, 69 (3), 609–620. DOI: 10.29356/jmcs.v69i3.2254.
• González-Periañez, S.; Hernández-Rosas, F.; López-Rosas, C. A.; et al. Multistage Molecular Simulations, Design, Synthesis, and Anticonvulsant Evaluation of 2-(Isoindolin-2-yl) Esters of Aromatic Amino Acids Targeting GABAA Receptors via π–π Stacking. J. Mol. Sci. 2025, 26 (14), 6780. DOI: 10.3390/ijms26146780.
• López-Rosas, C. A.; González-Periañez, S.; Pawar, T. J.; et al. Anticonvulsant Potential and Toxicological Profile of Verbesina persicifolia Leaf Extracts: Evaluation in Zebrafish Seizure and Artemia salina Toxicity Models. Plants 2025, 14 (7), 1078. DOI: 10.3390/plants14071078.
• Pawar, T. J.; Ramos-Cruz, S. X.; Bonilla-Landa, I.; Muteeb, G.; Delgado-Alvarado, E.; Patil, S. V.; Perez-Landa, I. D.; Olivares-Romero, J. L. Quantitative NMR for Detection of Spinosad Residues in Agricultural Soils. RSC Adv. 2025, 15 (7), 5547–5557. DOI: 10.1039/D5RA00356C.
• López-Carrillo, J.; Bernáldez-Sarabia, J.; Pawar, T. J.; Jiménez, S.; Dueñas, S.; et al. Systemic Antihyperalgesic Effect of a Novel Conotoxin from Californiconus californicus in an Inflammatory Pain Model. Pain Res. 2025, 5, 1500789. DOI: 10.3389/fpain.2024.1500789.
• Valencia, L.; Magaña, I.; Gálvez, M.; Enríquez-Medrano, F. J.; Córdova, T.; et al. Enhancing the Performance of Polyfarnesene-Based Bio-Rubbers with Surface-Modified Cellulose Nanocrystals and Nanofibers. Rep. 2025, 15 (1), 2906. DOI: 10.1038/s41598-024-84594-8.
• Rodríguez-Tobías, H.; Enríquez-Medrano, F. J.; Salinas-Hernández, M.; et al. Toward New Applications of Terpenes in Polymeric Materials: Synthesis and Characterization of Myrcene-Modified Unsaturated Polyester Resins. Appl. Polym. Sci. 2025, 142 (3), e56381. DOI: 10.1002/app.56381.
• Bhagwat, S. K.; Pawar, T. J.; Kulkarni, S. A.; Patil, A. A.; More, R. A.; et al. Synthesis, Characterization, Biological Activities, and Computational Studies of Pyrazolyl–Thiazole Derivatives of Thiophene. RSC Adv. 2024, 14 (52), 39004–39016. DOI: 10.1039/D4RA06228K.
• Delgado-Alvarado, E.; Figueroa-Navarro, M. A.; Martinez-Castillo, J.; et al. Sustainable, Eco-Friendly, and Cost-Effective Energy Generation Based on Coffee Grounds for Self-Powered Devices and Alarm Systems. Actuators, A 2024, 378, 115816. DOI: 10.1016/j.sna.2024.115816.
• Rodríguez-Becerra, S. H.; Vázquez-Rivera, R.; Ventura-Hernández, K. I.; et al. The Biology, Impact, and Management of Xyleborus Beetles: A Comprehensive Review. Insects 2024, 15 (9), 706. DOI: 10.3390/insects15090706.
• Pawar, T. J.; Bravo-Espinoza, I.; Delgado-Alvarado, E.; Ramos-Morales, F. R.; et al. Synthesis, Insecticidal Activities, Toxicity Assessment, and Environmental Implications of (R)- and (S)-Proline-Derived Chiral Neonicotinoid Derivatives. ACS Agric. Sci. Technol. 2024, 4 (9), 929–937. DOI: 10.1021/acsagscitech.4c00350.
• Ventura-Hernández, K. I.; Delgado-Alvarado, E.; Pawar, T. J.; et al. Chirality in Insecticide Design and Efficacy. Agric. Food Chem. 2024, 72 (38), 20722–20737. DOI: 10.1021/acs.jafc.4c05363.
• Jácome-Hernández, A.; Desgarennes, D.; Guevara, R.; Olivares-Romero, J. L.; Favila, M. E. Antifungal Capabilities of Gut Microbial Communities of Three Dung Beetle Species (Scarabaeidae: Scarabaeinae). Nat. 2024, 111, 36. DOI: 10.1007/s00114-024-01923-7.
• Pawar, T. J.; Jimenez-Halla, J. O. C.; Martinez-Valencia, D. I.; Kokate, S. V.; Delgado-Alvarado, E.; Olivares-Romero, J. L. Investigation of Enantioselectivity Using TADDOL Derivatives as Chiral Ligands in Asymmetric Cyanation Reactions. ACS Omega 2024, 9 (26), 29035–29040. DOI: 10.1021/acsomega.4c04399.
• Chandole, P. K.; Pawar, T. J.; Olivares-Romero, J. L.; Tivari, S. R.; Garcia Lara, B.; et al. Exploration of Novel Cationic Amino Acid-Enriched Short Peptides: Design, SPPS, Biological Evaluation and In Silico Study. RSC Adv. 2024, 14 (25), 17710–17723. DOI: 10.1039/D3RA08313F.
• Barrera-Méndez, F.; Licona Velázquez, L. S.; Miranda-Sánchez, D.; et al. Nanoencapsulation of Antifungal Piper schlechtendalii Extract in Poly(lactide-co-glycolic) Acid to Enhance Photostability. Mex. Chem. Soc. 2024, 68 (2), 332–343. DOI: 10.29356/jmcs.v68i2.1964.
• Reyes-Luna, A.; Yáñez-Barrientos, E.; Alba-Mares, X. N.; Olivares-Romero, J. L.; Alonso-Castro, Á. J.; Cruz Cruz, D.; Villegas Gómez, C. Metabolomic Approaches in Assessing the Insecticidal Activity of the Extracts from Argemone ochroleuca Sweet (Papaveraceae) against Three Diverse Crop Pests of Economic Importance. Biodiversity 2024, 21 (2), e202301279. DOI: 10.1002/cbdv.202301279.
• Pawar, T. J.; Valtierra-Galvan, M. F.; Rodriguez-Hernandez, A.; Reyes-Luna, A.; et al. Synthesis of Novel C2 Bishydroxamic Acid Ligands and Their Application in Asymmetric Epoxidation Reactions. Synlett 2023, 34 (20), 2496–2502. DOI: 10.1055/s-0042-1751481.
• Pawar, T. J.; Ventura-Hernández, K. I.; Ramos-Morales, F. R.; Olivares-Romero, J. L. Chiral Hydroxamic Acid Ligands in the Asymmetric Synthesis of Natural Products. Chemistry 2023, 5 (4), 2700–2712. DOI: 10.3390/chemistry5040174.
• Pawar, T. J.; Olivares-Romero, J. L.; Delgado-Alvarado, E.; Martinez-Castillo, J.; et al. Synthesis and Insecticidal Activity of Nitroguanidines Featuring R- and S-Proline. In 2023 IEEE International Conference on Engineering Veracruz (ICEV); IEEE, 2023; pp 1–5. DOI: 10.1109/ICEV59168.2023.10329640.
• Toledo-Hernandez, E. M.; Contreras-López, D.; Pérez-López, E.; et al. Silane Coupling Agents with Imidazoles Superficially Modify Titanium Dioxide. Soft Mater. 2023, 21 (4), 388–410. DOI: 10.1080/1539445X.2023.2278203.
• Pawar, T. J.; Barcelona-Cazanave, L.; Bonilla-Landa, I.; Escobar, M.; et al. New Synthetic Pathways to the Anastrepha ludens Host Marking Pheromone: Harnessing Iridium-Catalysis with Novel P,N-Ligand for Enantioselective Construction. Chem. Front. 2023, 10 (19), 4827–4835. DOI: 10.1039/D3QO01093G.
• Rodríguez-Hernández, A.; Bonilla-Landa, I.; Vidal-Limon, A.; et al. Synthesis, Insecticidal Activity, and Ensembled Docking of Nitroguanidines Bearing S- and R-Proline. Pest Manage. Sci. 2023, 79 (5), 1912–1921. DOI: 10.1002/ps.7368.
• Colorado-Peralta, R.; Olivares-Romero, J. L.; Rosete-Luna, S.; et al. Copper-Coordinated Thiazoles and Benzothiazoles: A Perfect Alliance in the Search for Compounds with Antibacterial and Antifungal Activity. Inorganics 2023, 11 (5), 185. DOI: 10.3390/inorganics11050185.
• Pawar, T. J.; Contreras López, D.; Olivares Romero, J. L.; Vallejo Montesinos, J. Surface Modification of Titanium Dioxide. Mater. Sci. 2023, 58 (16), 6887–6930. DOI: 10.1007/s10853-023-08439-x.
• Pawar, T. J.; Bonilla-Landa, I.; Reyes-Luna, A.; Barrera-Méndez, F.; Enríquez-Medrano, F. J.; Díaz-de-León-Gómez, R. E.; Olivares-Romero, J. L. Chiral Hydroxamic Acid Ligands in Asymmetric Synthesis: The Evolution of Metal-Catalyzed Oxidation Reactions. ChemistrySelect 2023, 8 (11), e202300555. DOI: 10.1002/slct.202300555.
• Lázaro-Rangel, J. M.; Sánchez, A.; Inoue, M.; Olivares-Romero, J. L.; Virués, C.; Domínguez, Z. Natural Eutectic Solvent Mixture of l-Menthol/Malonic Acid (4:1) and Its Ibuprofen Solution: Thermal and Physical Characterizations and NMR Studies of Molecular Interaction. J. Org. Chem. 2023, 26 (5), e202201326. DOI: 10.1002/ejoc.202201326.

 Patentes

• MX/a/2021/016129
• MX/a/2022/003853